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p90 RSK1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP, ICC |
|---|---|
| Primary Accession | Q15418 |
| Other Accession | NP_002944.2 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Bovine |
| Clonality | Polyclonal |
| Description | Rabbit Anti-Human p90 RSK1 Polyclonal |
| Target/Specificity | Detects ~90kDa. |
| Other Names | RSK1 p90 Antibody, HU1 Antibody, MAPKAP Antibody, p90rsk Antibody, p90S6K Antibody, RSK1 Antibody, RSK 1 p90 Antibody |
| Immunogen | Human p90 RSK1 C-terminal peptide, conjugated to KLH |
| Purification | Protein A Purified |
| Storage | -20ºC |
| Storage Buffer | TBS, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 0.25 mg/ml was sufficient for detection of SPC-147 in lysates prepared from mouse brain, spleen and intestine. |
| Cellular Localization | Cytoplasm | Nucleus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1–4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation. (1-5).
References
1. Roux, P. (2007). UCSD-Nature Molecule Pages.
2. Fro¨din, M. and Gammeltoft, S. (1999) Mol. Cell. Endocrinol. 151: 65-77.
3. Merienne, K. et al. (1998) J. Med. Genet. 35: 890-894.
4. De Cesare, D. et al. (1998) Proc. Natl. Acad. Sci. 95: 12202-12207.
5. Joel, P. B. et al. (1998) Mol. Cell. Biol. 18: 1978-1984.
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