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Mitofusin 2 Antibody
Mitofusin 2 Antibody, Clone S153-5
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC |
|---|---|
| Primary Accession | Q80U63 |
| Other Accession | NP_573464.2 |
| Host | Mouse |
| Isotype | IgG2a |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Human Mitofusin 2 Monoclonal IgG2a |
| Target/Specificity | Detects ~90kDa. No cross-reactivity against Mitofusin-1. |
| Other Names | CMT2A Antibody, CMT2A2 Antibody, CPRP 1 Antibody, CPRP1 Antibody, Fzo Antibody, HSG Antibody, hyperplasia suppressor gene Antibody, Hypertension related protein 1 Antibody, KIAA0214 Antibody, MARF Antibody, MFN 2 Antibody, Mfn2 Antibody, Mitochondrial assembly regulatory factor Antibody, Mitofusin-2 Antibody, Mitofusin2 Antibody, Transmembrane GTPase MFN2 Antibody |
| Clone Names | S153-5 |
| Immunogen | Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1. |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH 7.4, 50% glycerol, 0.1% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-457 was sufficient for detection of Mitofusin-2 in 20 µg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Mitochondrion | Mitochondrion Outer Membrane |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression.
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