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LRRK2/Dardarin Antibody
LRRK2/Dardarin Antibody, Clone S231B-34
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC, ICC |
|---|---|
| Primary Accession | Q5S007 |
| Other Accession | NP_940980 |
| Host | Mouse |
| Isotype | IgG2a |
| Reactivity | Human, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Human LRRK2/Dardarin Monoclonal IgG2a |
| Target/Specificity | Detects >200kDa. |
| Other Names | Leucine-rich repeat kinase 2 Antibody, RIP7 Antibody, PARK8 Antibody, Dardarin Antibody, ROCO 2 Antibody, RIPK7 Antibody, Leucine-rich repeat serine/threonine-protein kinase 2 Antibody, augmented in rheumatoid arthritis 17 Antibody |
| Clone Names | S231B-34 |
| Immunogen | Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. <30% identity with LRRK1. |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH 7.4, 50% glycerol, 0.1% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 10 µg/ml of SMC-445 was sufficient for detection of LRRK2/Dardarin in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cytoplasm | Membrane | Mitochondrion | Golgi Apparatus | Cell Projection | Axon | Dendrite | Endoplasmic Reticulum | Cytoplasmic Vesicle | Endosome | Lysosome |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.
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