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GluN2A/NR2A Antibody
GluN2A/NR2A Antibody, Clone S327A-38
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC |
|---|---|
| Primary Accession | Q00959 |
| Other Accession | NP_036705.3 |
| Host | Mouse |
| Isotype | IgG2b |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Rat GluN2A/NR2A Monoclonal IgG2b |
| Target/Specificity | Detects ~170kDa. Does not react with NR2B. |
| Other Names | NMDA 2A Antibody, NMDAR2A Antibody, NMDAR 2A Antibody, NMDA Receptor 2A Antibody, Glutamate Receptor Antibody, GRIN2A Antibody, Glutamate [NMDA] Receptor subunit epsilon-1 Antibody, Glutamate receptor ionotropic N methyl D aspartate 2A Antibody, HNR2A Antibody, N methyl D aspartate receptor channel Antibody, subunit epsilon 1 Antibody, N Methyl D Aspartate Receptor Subtype 2A Antibody, N methyl D aspartate receptor subunit 2A Antibody, NMDA receptor subtype 2A Antibody, NMDA Receptor Type 2A Antibody, OTTHUMP00000160135 Antibody, OTTHUMP00000174531 Antibody |
| Clone Names | S327A-38 |
| Immunogen | Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-434 was sufficient for detection of GluN2A/NR2A in 20 µg of COS cells transiently transfected with GFP-tagged NR2A lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cell Membrane | Cell Junction |
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Provided below are standard protocols that you may find useful for product applications.
Background
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D).
References
1. Teng H.J., et al. (2010) PLoS ONE. 5: e13342.
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