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TARP Gamma2/4/8 (Stargazin) Antibody
TARP Gamma2/4/8 (Stargazin) Antibody, Clone S245-36
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q71RJ2 |
| Other Accession | NP_445803.1 |
| Host | Mouse |
| Isotype | IgG2A |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Rat TARP Gamma2/4/8 (Stargazin) Monoclonal IgG2A |
| Target/Specificity | Detects ~35-55kDa. Does not cross-react with TARPGamma3. |
| Other Names | CACNG2 Antibody, Calcium channel voltage dependent gamma subunit 2 Antibody, CaV gamma 2 Antibody, Ipr328 Antibody, MGC123981 Antibody, MGC138502 Antibody, MGC138504 Antibody, Voltage-dependent calcium channel gamma-2 subunit Antibody, Neuronal voltage-gated calcium channel gamma-2 subunit Antibody, Stargazin Antibody, Stg Antibody, Stargazer Antibody, TARP Antibody, TARP gamma-2 Antibody, Transmembrane AMPAR regulatory protein gamma-2 Antibody, AW060990 Antibody, B230105C07Rik Antibody, B930041E13Rik Antibody, Wag Antibody, Waggler Antibody |
| Clone Names | S245-36 |
| Immunogen | Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2 |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-422 was sufficient for detection of TARP Gamma2/4/8 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state. There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival.
References
1. Gill M.B., et al. (2011) J Neurosci. 31(18): 6928-6938.
2. Yu L. (2011) Neuroscience. 178: 13-20.
3. Steinmetz C.C., Turrigiano G.G. (2010) J Neurosci. 30: 14685-14690.
4. Kato. A.S. et al. (2007) J Neurosci. 27: 4969-4977.
5. Letts V.A., et al. (1998) Nat Genet. 19: 340-34
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