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mGluR1/5 Antibody
mGluR1/5 Antibody, Clone S75-33
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, IP |
|---|---|
| Primary Accession | P31424 |
| Other Accession | NP_058708.1 |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Rat mGluR1/5 Monoclonal IgG1 |
| Target/Specificity | Detects ~130kDa (both mGluR1 and mGluR5). |
| Other Names | Glutamate receptor metabotropic 5, GPRC1E Antibody, GRM 5 Antibody, GRM5 Antibody, Metabotropic glutamate receptor 5 Antibody, Metabotropic glutamate receptor 5 variant F Antibody, Metabotropic glutamate receptor 5 variant G Antibody, Metabotropic glutamate receptor 5 variant H Antibody, mGlu5 Antibody, mGluR5 Antibody, mGluR5a Antibody, mGluR5b Antibody, Glutamate receptor metabotropic 1 Antibody, glutamate receptor Antibody, metabotropic 1 Antibody, GPRC1A Antibody, GRM 1 Antibody, GRM1 alpha Antibody, GRM1 Antibody, GRM1_HUMAN Antibody, GRM1A Antibody, Metabotropic glutamate receptor 1 Antibody, mGlu1 Antibody, mGluR1 alpha Antibody, mGluR1 Antibody, mGluR1A Antibody |
| Clone Names | S75-33 |
| Immunogen | Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-407 was sufficient for detection of mGluR1/5 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cell Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
The AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the CNS. AMPARs are composed of four types of subunits, designated as GluR1, GluR2, GluR3 and GluR4, which combine to form tetramers (1,2).
References
1. Mayer M.L. (2005) Current Opinion in Neurobio. 15(3): 282-288.
2. Keinane K., et al. (1990) Science. 249: 556-560.
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