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GluN2B/NR2B Antibody
GluN2B/NR2B Antibody, Clone S59-36
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, IP, AM |
|---|---|
| Primary Accession | Q00960 |
| Other Accession | NP_036706.1 |
| Host | Mouse |
| Isotype | IgG2b |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Rat GluN2B/NR2B Monoclonal IgG2b |
| Target/Specificity | Detects ~166kDa. No cross-reactivity against NR2A. |
| Other Names | NMDAR2B Antibody, hNR3 Antibody, MGC142180 Antibody, glutamate receptor subunit epsilon-2 Antibody, NR3 Antibody |
| Clone Names | S59-36 |
| Immunogen | Fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-337 was sufficient for detection of NR2B in 10 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
NR2B containing receptors have been implicated in synaptic plasticity, memory formation and pain modulation (1). Studies suggest that the NR2B subunit of glutamate receptors may be potential targets for relieving pain; NR2B may be a probable target for anti-nociceptive drugs, and may also be useful as analgesics (2).
References
1. Zhuo M. (2009) Mol Brain. 2(1): 4
2. Gurwitz D, and Weizman A. (2002) Drug Discovery Today, 7(7): 403-406.
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