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Cav beta 2 Antibody
CavBeta2 Antibody, Clone S8B-1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, IP, AM |
|---|---|
| Primary Accession | Q8VGC3 |
| Other Accession | NP_446303 |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Rat Cav beta 2 Monoclonal IgG1 |
| Target/Specificity | Detects ~78 kDa. No cross reactivity against Cavβ1, Cavβ3, Cavβ4. |
| Other Names | Cacnlb2 Antibody, cacnb2 Antibody, Voltage-dependent L-type calcium channel subunit beta-2 Antibody, CAB2 Antibody |
| Clone Names | S8B-1 |
| Immunogen | Synthetic peptide amino acids 189-205 of rat CavBeta2 |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-332 was sufficient for detection of Cavβ2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody |
| Cellular Localization | Cell Membrane | Sarcolemma |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cav Beat subunits are involved in the transport of the pore forming alpha1 subunit to the plasma membrane (1). They also shield an ER Retention signal on the alpha1 subunit, thereby guiding the pore-forming subunit to the target membrane (2, 3). They also determine the biophysical properties of the calcium channel (3).
References
1. Dolphin A.C. (2003) J Bioenerg. Biomembr. 35: 599-620.
2. Bichet D., et al. (2000) Neuron. 25: 177-190.
3. Xie M., et al. (2007) J Cell Biol. 178(3): 489-502.
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