NDST1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P52848 |
Other Accession | NP_001534 |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Clone Names | NDST1 |
Calculated MW | Predicted: 97 kDa Observed: 97 kDa |
Gene ID | 15531 |
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Alias Symbol | NDST1 |
Other Names | NDST1 Antibody: HSST, NST1, MRT46 |
Target/Specificity | NDST1 Antibody is predicted to not cross-react with NDST2. |
Reconstitution & Storage | NDST1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Precautions | NDST1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NDST1 (HGNC:7680) |
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Synonyms | HSST, HSST1 |
Function | [Isoform 1]: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:35137078, PubMed:9230113, PubMed:9744796). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:9230113). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). |
Cellular Location | [Isoform 1]: Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein |
Tissue Location | Widely expressed. Expression is most abundant in heart, liver and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
NDST1 is a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. It is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate.
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