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CHADL Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q6NUI6 |
| Other Accession | NP_612490, 150356 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 84 kDa Observed: 86 kDa |
| Application Notes | CHADL antibody can be used for the detection of CHADL by Western blot at 1 - 2 μg/mL. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. |
| Gene ID | 150356 |
|---|---|
| Target/Specificity | CHADL antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human CHADL. The immunogen is located within the last 50 amino acids of CHADL. |
| Reconstitution & Storage | CHADL antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | CHADL Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CHADL |
|---|---|
| Synonyms | SLRR4B |
| Function | Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment. |
| Cellular Location | Secreted. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:E9Q7T7} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The Chondroadherin-like (CHADL) protein, also known as SLRR4B, is homologous to the Chondroadherin protein and is expressed cartillaginous tissues (1). Like Chondroadherin, CHADL belongs to the small leucine-rich proteoglycan (SLRP) family and class IV subfamily and plays a significant role in the regulation of chondrocyte growth and proliferation (1,2). CHADL is thought to play a negative regualtory role in collagen fibrillogenesis and chondrocyte differentiation (1).
References
Tillgren V, Ho JC, Onnerfjord P, et al. The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentitation. J. Biol. Chem. 2015; 290:918-25.
Neame PJ, Sommarin Y, Boynton RE, et al. The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilage. J. Biol. Chem. 1994; 269:21547-54.
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