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FOXG1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P55316 |
| Other Accession | NP_005240, 32307177 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 54 kDa Observed: 54 kDa |
| Application Notes | FOXG1 antibody can be used for detection of FOXG1 by Western blot at 1 - 2 µg/ml. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 2290 |
|---|---|
| Target/Specificity | FOXG1; FOXG1 antibody is human, mouse and rat reactive. |
| Reconstitution & Storage | Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | FOXG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FOXG1 |
|---|---|
| Function | Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:21280142} |
| Tissue Location | Expression is restricted to the neurons of the developing telencephalon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
FOXG1 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain and plays an important role in the development of the brain and telencephalon (1). It is essential for the proliferation of progenitor cells in the cerebral cortex and influences regional patterning in the mammalian telencephalon (2,3). Expression is restricted to the neurons of the developing telencephalon (3). The loss of FOXG1 results in an accelerated rate of neuronal differentiation and the shortening of the neurogenetic period in the embryonic cerebral cortex (2,4).
References
Murphy DB, Wiese S, Burfeind P, et al. Human brain factor 1, a new member of the fork head gene family. Genomics 1994; 21:551-7.
Kumamoto T, Toma K, Gunadi, et al. Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression. Cell Rep. 2013; 3:931-45.
Miyoshi G and Fishell G. Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate. Neuron 2012;74:1045-58.
Mencarelli MA, Spanhol-Rosseto A, Artuso R, et al. Novel FOXG1 mutations associated with the congenital variant of Rett syndrome. J. Med. Genet. 2010; 47:49-53.
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