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PDCL Antibody

     
  • WB - PDCL Antibody ASC11819
    Western blot analysis of PDCL in K562 cell lysate with PDCL antibody at 1 µg/ml.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q13371
Other Accession NP_005379, 88758594
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 33 kDa

Observed: 35 kDa
Application Notes PDCL antibody can be used for detection of PDCL by Western blot at 1 - 2 µg/ml.
Additional Information
Gene ID 5082
Target/Specificity PDCL; PDCL antibody is human, mouse and rat reactive. At least two isoforms of PDCL are known to exist. PDCL antibody is predicted to not cross-react with other members of the PDCL protein family.
Reconstitution & Storage PDCL antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsPDCL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDCL
Synonyms PHLOP1, PhLP1
Function Acts as a positive regulator of hedgehog signaling and regulates ciliary function. [Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.
Cellular Location Cell projection, cilium {ECO:0000250|UniProtKB:Q9DBX2}
Citations (0)
citation

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Background

Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1,2). PDCL is widely expressed in normal human tissues and may participate directly in the regulation of calcium-evoked exocytosis in adrenal medullary chromaffin cells (3). It is an ethanol-responsive modulator of heterotrimeric G proteins (4).

References

Miles MF, Barhite S, Sganga M, et al. Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc. Natl. Acad. Sci. USA 1993; 90:10831-5.
Ruiz-Gomez A, Humrich J, Murga C, et al. Phosphorylation of phosducin and phosducinlike protein by G protein-coupled receptor kinase 2. J. Biol. Chem. 2000; 275:29724-30.
Gensse M, Vitale N, Chasserot-Golaz S, et al. Regulation of exocytosis in chromaffin cells by phosducin-like protein, a protein interacting with G protein betagamma-subunits. FEBS Lett. 2000; 480:184-8.
Barhite S, Thibault C, Miles MF, et al. Phosducin-like protein (PhLP), a regulator of G beta gamma function, interacts with the proteasomal protein SUG1. Biochim. Biophys. Acta 1998; 1402: 95-101.

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$ 379.00
Cat# ASC11819
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