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IL-28B Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q8IZI9 |
| Other Accession | NP_742151, 28144901 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 20 kDa Observed: 16kDa |
| Application Notes | IL-28B antibody can be used for detection of IL-28B by Western blot at 1 - 2 µg/ml. |
| Gene ID | 282617 |
|---|---|
| Target/Specificity | IFNL3; IL-28B antibody is human specific. IL-28B antibody may cross-react with IL-28A and IL-29. |
| Reconstitution & Storage | IL-28B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | IL-28B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IFNL3 |
|---|---|
| Synonyms | IL28B, IL28C, ZCYTO22 |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)- induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Cellular Location | Secreted. |
Research Areas
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$ 379.00
Cat# ASC11700
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