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CEACAM5 Antibody

     
  • WB - CEACAM5 Antibody  ASC11690
    Western blot analysis of CEACAM5 in rat lung tissue lysate with CEACAM5 antibody at (A) 1 and (B) 2 µg/ml.
    detail
  • IF - CEACAM5 Antibody  ASC11690
    Immunofluorescence of CEACAM5 in human lung tissue with CEACAM5 antibody at 20 µg/mL.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P06731
Other Accession NP_004354, 98986445
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 77 kDa

Observed: 80kDa
Application Notes CEACAM5 antibody can be used for detection of CEACAM5 by Western blot at 1 - 2 µg/ml.
Additional Information
Gene ID 1048
Target/Specificity CEACAM5; CEACAM5 antibody is human, mouse and rat reactive. CEACAM5 antibody is predicted to not cross-react with other CEACAM protein family members.
Reconstitution & Storage CEACAM5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsCEACAM5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CEACAM5
Synonyms CEA
Function Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface Note=Localized to the apical glycocalyx surface
Tissue Location Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Research Areas
Citations (0)
citation

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Background

CEACAM5 is a member of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily (1,2). CEACAM proteins are involved in cell-cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation (2). CEACAM5 has been shown to be overexpressed in a majority of carcinomas and has been suggested to be a intercellular adhesion molecule involved in cancer invasion and metastasis (3).

References

Gold P and Freedman SO. Specific carinoembryonic antigens of the human digestive system. J. Exp. Med. 1965; 122:467-81.
Kuespert K, Pils S, and Hauck CR. CEACAMs: their role in physiology and pathophysiology. Curr. Opin. Cell Biol. 2006; 565-71.
Yoshioka T, Masuko T, Kotanagi H, et al. Homotypic adhesion though carcinoembryonic antigen plays a role in hepatic metastasis development. Jpn. J. Cancer Res. 1998; 89:177-85.

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$ 379.00
Cat# ASC11690
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