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SLC27A6 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | Q9Y2P4 |
| Other Accession | NP_054750, 28965 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 68 kDa Observed: 68 kDa |
| Application Notes | SLC27A6 antibody can be used for detection of SLC27A6 by Western blot at 1 - 2 μg/mL. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL. |
| Gene ID | 28965 |
|---|---|
| Target/Specificity | SLC27A6 antibody was raised against a 16 amino acid peptide near the amino terminus of human SLC27A6. The immunogen is located within amino acids 180 - 230 of SLC27A6. |
| Reconstitution & Storage | SLC27A6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | SLC27A6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC27A6 |
|---|---|
| Synonyms | ACSVL2, FACVL2, FATP6 |
| Function | Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:12556534). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long- chain fatty acids (VLCFA) as substrates (By similarity). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation such as the heart (PubMed:12556534). |
| Cellular Location | Cell membrane, sarcolemma; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:E9Q9W4}; Multi-pass membrane protein. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. |
| Tissue Location | Strongly expressed in heart and localizes to cardiac myocytes (PubMed:12556534). Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC27A6 Antibody: The solute carrier family 27 (fatty acid transporter), member 6 (SLC27A6) is a member of the fatty acid transport protein family (FATP), which are involved in the uptake of long-chain fatty acids. SLC27A6 is principally expressed in the heart on the sarcolemma and colocalizes with CD36, another molecule involved in the uptake of long chain fatty acids.
References
Gimeno RE, Ortegon AM, Patel S, et al. Characterization of a heart-specific fatty acid transport protein. J. Biol. Chem. 2003;278:16039-44.
Fisher RM and Gertow K. Fatty acid transport proteins and insulin resistance. Curr. Opin. Lipidol. 2005; 16:173-8.
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