TNFSF4 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | P23510 |
Other Accession | NP_003317, 4507603 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 20 kDa |
Application Notes | TNFSF4 antibody can be used for detection of TNFSF4 by Western blot at 0.5 - 1 µg/mL. |
Gene ID | 7292 |
---|---|
Target/Specificity | TNFSF4; At least two isoforms of TNFSF4 are known to exist; this antibody will detect both isoforms. |
Reconstitution & Storage | TNFSF4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
Precautions | TNFSF4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TNFSF4 |
---|---|
Synonyms | TXGP1 |
Function | Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. |
Cellular Location | Membrane; Single-pass type II membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TNFSF4 Antibody: The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
References
Arch RH and Thompson CB. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol. Cell Biol.1998; 18:558-65.
OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathy. Adv. Immunol. 2010; 105:63-98
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