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ApoA4 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P06727 |
| Other Accession | NP_990269, 337 |
| Reactivity | Human, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 45372 Da |
| Application Notes | ApoA4 antibody can be used for detection of ApoA4 by Western blot at 1 μg/mL. |
| Gene ID | 337 |
|---|---|
| Target/Specificity | ApoA4 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of chicken ApoA4. The immunogen is located within the last 50 amino acids of ApoA4. |
| Reconstitution & Storage | ApoA4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | ApoA4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APOA4 |
|---|---|
| Function | May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. |
| Cellular Location | Secreted. |
| Tissue Location | Synthesized primarily in the intestine and secreted in plasma |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ApoA4 Antibody: Apolipoprotein A4 (also known as ApoA-IV) is a plasma protein that is O-linked glycoprotein after proteolytic processing. ApoA4 is a major constituent of HDL and it also can be found on the surface of newly synthesized chylomicrons. The physiological function of ApoA4 is not completely identified so far, but several evidences from vitro studies indicate that this apolipoprotein involves in several steps of the reverse cholesterol transport pathway, which transports cholesterol from peripheral cells back to the liver.
References
Karathanasis SK, Oettgen P, Haddad IA, et al. Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). Proc. Natl. Acad. Sci. 1986; 83:8457-61
Kamboh MI, Friedlaender JS, Ahn YI et al. A common deletion polymorphism in the apolipoprotein A4 gene and tis significance in lipid metabolism. Arterioscler. Thromb. 1994; 14:656-62.
Kronenberg F, Stuhlinger M, Trenkwalder E, et al. Low apolipoprotein A-IV plasma concentrations in men with coronary artery disease. J. Am. Coll. Cardiol., 2000; 36:751-7
Von Eckardstein A, Huang Y, Wu S, et al. Lipoproteins containing apolipoprotein A-IV but not apolipoprotein A-I take up and esterify cell-derived cholesterol in plasma. Arterioscler Thromb Vasc Biol. 1995; 15:1755-63.
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