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RSRC1 Antibody

     
  • WB - RSRC1 Antibody ASC11068
    Western blot analysis of RSRC1 in HepG2 cell lysate with RSRC1 antibody at (A) 1 and (B) 2 µg/mL.
    detail
  • IHC - RSRC1 Antibody ASC11068
    Immunohistochemistry of RSRC1 in rat liver tissue with RSRC1 antibody at 5 µg/mL.
    detail
  • IF - RSRC1 Antibody ASC11068
    Immunofluorescence of RSRC1 in rat liver tissue with RSRC1 antibody at 20 µg/mL.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q96IZ7
Other Accession NP_057709, 38488727
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 38677 Da
Application Notes RSRC1 antibody can be used for detection of RSRC1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 51319
Target/Specificity RSRC1;
Reconstitution & Storage RSRC1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsRSRC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RSRC1
Synonyms SRRP53
Function Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing.
Cellular Location Nucleus. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm.
Tissue Location Widely expressed. Expressed in brain, spinal cord, cerebellum.
Research Areas
Citations (0)
citation

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Background

RSRC1 Antibody: The arginine/serine-rich coiled-coil 1 protein (RSRC1) was initially identified as a non-snRNP splicing factor that has a role in both the constitutive and alternative splicing of pre-mRNA molecules. In cellular nuclear extracts immunodepleted of RSRC1, the second step of pre-mRNA splicing is blocked; recombinant RSRC1 is able to restore splicing activity. RSRC1 has also been reported to be associated with schizophrenia as well as a unique marker of bone marrow-derived stem cells that also express the cdc34 marker.

References

Cazalla D, Newton K, and Caceres JF. A noel SR-related protein is required for the second step of pre-mRNA splicing. Mol. Cell. Biol.2005; 25:2969-80.
Potkin SG, Turner JA, Fallon JA, et al. Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. Mol. Psych.2009; 14:416-28.
Zhang QH, Ye M, Wu XY, et al. Cloning and functional analysis of cDNAs with open reading frames for 300 previously unidentified genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res./i> 2008; 18:640-3.

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$ 379.00
Cat# ASC11068
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