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CLDN1 Antibody

     
  • WB - CLDN1 Antibody ASC10912
    Western blot analysis of CLDN1 in HepG2 cell lysate with CLDN1 antibody at (A) 1 and (B) 2 µg/mL.
    detail
  • ICC - CLDN1 Antibody ASC10912
    Immunocytochemistry of CLDN1 in HepG2 cells with CLDN1 antibody at 5 µg/mL.
    detail
  • IF - CLDN1 Antibody ASC10912
    Immunofluorescence of CLDN1 in HepG2 cells with CLDN1 antibody at 20 µg/mL.
    detail
Western blot analysis of CLDN1 in HepG2 cell lysate with CLDN1 antibody at (A) 1 and (B) 2 µg/mL.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IF, ICC, E
Primary Accession O95832
Other Accession CAG33419, 48146393
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 22744 Da
Application Notes CLDN1 antibody can be used for detection of CLDN1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunocytochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 9076
Target/Specificity CLDN1;
Reconstitution & Storage CLDN1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsCLDN1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLDN1
Synonyms CLD1, SEMP1
Function Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
Cellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Tissue Location Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
Research Areas
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$ 379.00
Cat# ASC10912
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