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FEZ2 Antibody

     
  • WB - FEZ2 Antibody ASC10615
    Western blot analysis of FEZ2 in mouse brain tissue lysate with FEZ2 antibody at (A) 0.5, and (B) 1 µg/mL.
    detail
  • IF - FEZ2 Antibody ASC10615
    Immunofluorescence of human brain tissue using FEZ25 antibody at 5 µg/mL.
    detail
  • IF - FEZ2 Antibody ASC10615
    Immunofluorescence of FEZ2 in Human Brain cells with FEZ2 antibody at 5 µg/mL.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IF, E
Primary Accession Q9UHY8
Other Accession NP_001036013, 110349756
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 39666 Da
Application Notes FEZ2 antibody can be used for the detection of FEZ2 by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunoflourescence starting at 5 µg/mL. For immunofluorescence start at 5 µg/mL.
Additional Information
Gene ID 9637
Target/Specificity FEZ2;
Reconstitution & Storage FEZ2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsFEZ2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FEZ2
Function Involved in axonal outgrowth and fasciculation.
Tissue Location Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and melanocytes
Research Areas
Citations (0)
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Background

FEZ2 Antibody: Fasciculation and elongation protein zeta-2 (FEZ2) is a homolog to the mammalian FEZ1, itself an ortholog of the C. elegans UNC-76. In contrast to FEZ1, FEZ2 mRNA is widely expressed in mouse tissues. FEZ2 interacts with protein kinase C (PKC)-zeta substrate and induces neurite extension of PC12 cells when co-expressed with a constitutively active form of PKC-zeta, suggesting FEZ2 may play an important role in the morphological changes of various cells by associating with PKC-zeta in a tissue non-specific manner. FEZ2 can interact with FEZ1 through its c-terminal regions and especially its coiled-coil region. At least two isoforms of FEZ2 are known to exist.

References

Fujita T, Ikuta J, Okajima T, et al. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Biochem. Biophys. Res. Commun.2004; 313:738-44.
Kuroda S, Nakagawa N, Tokunaga C, et al. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C z-interacting protein. J. Cell Biol.1999; 144:403-11.
Assmann EM, Alborghetti MR, Camargo MER, et al. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. J. Biol. Chem.2006; 281:9869-81.

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$ 379.00
Cat# ASC10615
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