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NIK Antibody
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q99558 |
| Other Accession | Q99558, 9020 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 104 kDa |
| Application Notes | NIK antibody can be used for detection of NIK by Western blot at 1 - 2 μg/mL. |
| Gene ID | 9020 |
|---|---|
| Other Names | NIK Antibody: HS, NIK, HSNIK, FTDCR1B, Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, HsNIK, mitogen-activated protein kinase kinase kinase 14 |
| Target/Specificity | NIK antibody was raised against a 17 amino acid peptide near the carboxy terminus of human NIK. The immunogen is located within the last 50 amino acids of NIK. |
| Reconstitution & Storage | NIK antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | NIK Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAP3K14 (HGNC:6853) |
|---|---|
| Function | Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon |
Research Areas
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