Anti-TGFb1 Reference Antibody (Genzyme patent anti-TGF-β)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, E, FTA |
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Primary Accession | P01137 |
Reactivity | Rat, Human, Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Calculated MW | 145 KDa |
Target/Specificity | TGFb1 |
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Endotoxin | < 0.001EU/ µg,determined by LAL method. |
Conjugation | Unconjugated |
Expression system | CHO Cell |
Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
Name | TGFB1 (HGNC:11766) |
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Synonyms | TGFB |
Function | Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. |
Cellular Location | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix |
Tissue Location | Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158) |
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