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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-CXADR Reference Antibody (Med. Bio. Labs patent anti-CXADR)
Anti-CXADR Reference Antibody (Med. Bio. Labs patent anti-CXADR)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, E, FTA |
|---|---|
| Primary Accession | P78310 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | IgG2SA |
| Calculated MW | 150 KDa |
| Target/Specificity | CXADR |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Name | CXADR |
|---|---|
| Synonyms | CAR |
| Function | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3- kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797). [Isoform 4]: Secreted |
| Tissue Location | Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. |
Research Areas
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$ 385.00
Cat# APR10869
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