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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-IL-1R1 / CD121a Reference Antibody (AMG 108)
Anti-IL-1R1 / CD121a Reference Antibody (AMG 108)
Recombinant Antibody
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- BACKGROUND
Application 
| FC, E, FTA |
|---|---|
| Primary Accession | P14778 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | IgG2SA |
| Calculated MW | 150 KDa |
| Target/Specificity | IL-1R1 / CD121a |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Name | IL1R1 |
|---|---|
| Synonyms | IL1R, IL1RA, IL1RT1 |
| Function | Receptor for IL1A, IL1B and IL1RN (PubMed:2950091, PubMed:37315560). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa- B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). |
| Cellular Location | Membrane; Single- pass type I membrane protein. Cell membrane. Secreted |
| Tissue Location | Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. |
Research Areas
Citations (0)
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Application Protocols
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$ 365.00
Cat# APR10710
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