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Anti-DKK1 Reference Antibody (BHQ-880)

Recombinant Antibody

     
  •  - Anti-DKK1 Reference Antibody (BHQ-880) APR10701
    Anti-DKK1 Reference Antibody (BHQ-880) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
    detail
  •  - Anti-DKK1 Reference Antibody (BHQ-880) APR10701
    The purity of Anti-DKK1 Reference Antibody (BHQ-880)is more than 100% ,determined by SEC-HPLC.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC, E, FTA
Primary Accession O94907
Reactivity Cynomolgus, Human, Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 142.96 KDa
Additional Information
Target/Specificity DKK1
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name DKK1
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Cellular Location Secreted.
Tissue Location Placenta.
Research Areas
Citations (0)
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$ 365.00
Cat# APR10701
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Availability: 4 weeks
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