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Anti-CXCL8 / IL-8 Reference Antibody (ABX-IL8)

Recombinant Antibody

     
  •  - Anti-CXCL8 / IL-8 Reference Antibody (ABX-IL8) APR10687
    Anti-CXCL8 / IL-8 Reference Antibody (ABX-IL8) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
    detail
  •  - Anti-CXCL8 / IL-8 Reference Antibody (ABX-IL8) APR10687
    The purity of Anti-CXCL8 / IL-8 Reference Antibody (ABX-IL8)is more than 98.07% ,determined by SEC-HPLC.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC, E, FTA
Primary Accession P10145
Reactivity Human
Clonality Monoclonal
Isotype IgG2SA
Calculated MW 143.94 KDa
Additional Information
Target/Specificity CXCL8 / IL-8
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name CXCL8
Synonyms IL8
Function Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:18692776, PubMed:7636208). Also plays an important role in neutrophil activation (PubMed:2145175, PubMed:9623510). Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells (PubMed:1840701, PubMed:1891716). G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways (PubMed:11971003, PubMed:8662698).
Cellular Location Secreted.
Research Areas
Citations (0)
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$ 365.00
Cat# APR10687
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Availability: 4 weeks
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