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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-TNFSF5 / CD40L / CD154 Reference Antibody (dapirolizumab)
Anti-TNFSF5 / CD40L / CD154 Reference Antibody (dapirolizumab)
Recombinant Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| FC, E, FTA |
|---|---|
| Primary Accession | P29965 |
| Reactivity | Cynomolgus, Human |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 145 KDa |
| Target/Specificity | TNFSF5 / CD40L / CD154 |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Name | CD40LG |
|---|---|
| Synonyms | CD40L, TNFSF5, TRAP |
| Function | Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein. Cell surface |
| Tissue Location | Specifically expressed on activated CD4+ T- lymphocytes |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 365.00
Cat# APR10599
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