Anti-RGMC / HFE2 Reference Antibody (DISC-0974)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, E, FTA |
---|---|
Primary Accession | Q6ZVN8 |
Reactivity | Rat, Cynomolgus, Human |
Clonality | Monoclonal |
Isotype | IgG1 |
Calculated MW | 145.66 KDa |
Target/Specificity | RGMC / HFE2 |
---|---|
Endotoxin | < 0.001EU/ µg,determined by LAL method. |
Conjugation | Unconjugated |
Expression system | CHO Cell |
Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
Name | HJV (HGNC:4887) |
---|---|
Synonyms | HFE2, RGMC |
Function | Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966). |
Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor. Note=Also released in the extracellular space |
Tissue Location | Adult and fetal liver, heart, and skeletal muscle. |
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