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Anti-Adrenomedullin Reference Antibody (enibarcimab)

Recombinant Antibody

     
  •  - Anti-Adrenomedullin Reference Antibody (enibarcimab) APR10539
    Anti-Adrenomedullin Reference Antibody (enibarcimab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
    detail
  •  - Anti-Adrenomedullin Reference Antibody (enibarcimab) APR10539
    The purity of Anti-Adrenomedullin Reference Antibody (enibarcimab)is more than 100% ,determined by SEC-HPLC.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC, E, FTA
Primary Accession P35318
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 145.82 KDa
Additional Information
Target/Specificity Adrenomedullin
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name ADM (HGNC:259)
Synonyms AM
Function Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Cellular Location Secreted.
Tissue Location Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues
Research Areas
Citations (0)
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$ 365.00
Cat# APR10539
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Availability: 4 weeks
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