Anti-Adrenomedullin Reference Antibody (enibarcimab)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, E, FTA |
---|---|
Primary Accession | P35318 |
Reactivity | Rat, Human, Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Calculated MW | 145.82 KDa |
Target/Specificity | Adrenomedullin |
---|---|
Endotoxin | < 0.001EU/ µg,determined by LAL method. |
Conjugation | Unconjugated |
Expression system | CHO Cell |
Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
Name | ADM |
---|---|
Synonyms | AM |
Function | AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. |
Cellular Location | Secreted. |
Tissue Location | Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues |
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