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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-CCR5 / CD195 Reference Antibody (leronlimab)
Anti-CCR5 / CD195 Reference Antibody (leronlimab)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, E, FTA |
|---|---|
| Primary Accession | P51681 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | IgG4 |
| Calculated MW | 150 KDa |
| Target/Specificity | CCR5 / CD195 |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Name | CCR5 (HGNC:1606) |
|---|---|
| Synonyms | CMKBR5 |
| Function | Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 365.00
Cat# APR10518
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