Anti-ERBB3/ HER3 Reference Antibody (patritumab deruxtecan)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| FC, E, FTA |
---|---|
Primary Accession | P21860 |
Reactivity | Cynomolgus, Human, Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Calculated MW | 146.86 KDa |
Target/Specificity | ERBB3 / HER3 |
---|---|
Endotoxin | < 0.001EU/ µg,determined by LAL method. |
Conjugation | Dxd |
Expression system | CHO Cell |
Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
Name | ERBB3 |
---|---|
Synonyms | HER3 |
Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein |
Tissue Location | Epithelial tissues and brain. |

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