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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-ERBB3/ HER3 Reference Antibody (patritumab deruxtecan)
Anti-ERBB3/ HER3 Reference Antibody (patritumab deruxtecan)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, E, FTA |
|---|---|
| Primary Accession | P21860 |
| Reactivity | Cynomolgus, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 146.86 KDa |
| Target/Specificity | ERBB3 / HER3 |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Dxd |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Name | ERBB3 |
|---|---|
| Synonyms | HER3 |
| Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Epithelial tissues and brain. |
Research Areas
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$ 385.00
Cat# APR10048
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