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Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab)

Recombinant Antibody

     
  •  - Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab) APR10028
    Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
    detail
  •  - Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab) APR10028
    The purity of Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab)is more than 99.21% ,determined by SEC-HPLC.
    detail
  •  - Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab) APR10028
    Immobilized human TNFRSF5 / CD40 His at 2 µg/mL can bind Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab),EC50=0.0252 µg/mL.
    detail
  •  - Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab) APR10028
    Human CD40 CHO cells were stained with Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC77=0.6311 ug/mL
    detail
  •  - Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab) APR10028
    Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab) FACS Blocking was evaluated using CCRF-CEM. The IC50 was approximately 1.359 ug/mL.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC, E, FTA
Primary Accession P25942
Reactivity Cynomolgus, Human
Clonality Monoclonal
Isotype IgG4PE
Calculated MW 150 KDa
Additional Information
Target/Specificity TNFRSF5 / CD40
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name CD40
Synonyms TNFRSF5
Function Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).
Cellular Location [Isoform I]: Cell membrane; Single-pass type I membrane protein
Tissue Location B-cells and in primary carcinomas.
Research Areas
Citations (0)
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$ 365.00
Cat# APR10028
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Availability: 4 weeks
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