Anti-TNFRSF5 / CD40 Reference Antibody (bleselumab)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, E, FTA |
---|---|
Primary Accession | P25942 |
Reactivity | Cynomolgus, Human |
Clonality | Monoclonal |
Isotype | IgG4PE |
Calculated MW | 150 KDa |
Target/Specificity | TNFRSF5 / CD40 |
---|---|
Endotoxin | < 0.001EU/ µg,determined by LAL method. |
Conjugation | Unconjugated |
Expression system | CHO Cell |
Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
Name | CD40 |
---|---|
Synonyms | TNFRSF5 |
Function | Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). |
Cellular Location | [Isoform I]: Cell membrane; Single-pass type I membrane protein |
Tissue Location | B-cells and in primary carcinomas. |
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