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Anti-CALCRL / CGRPR Reference Antibody (erenumab)

Recombinant Antibody

     
  •  - Anti-CALCRL / CGRPR Reference Antibody (erenumab) APR10013
    Anti-CALCRL / CGRPR Reference Antibody (erenumab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
    detail
  •  - Anti-CALCRL / CGRPR Reference Antibody (erenumab) APR10013
    The purity of Anti-CALCRL / CGRPR Reference Antibody (erenumab)is more than 99.43% ,determined by SEC-HPLC.
    detail
  •  - Anti-CALCRL / CGRPR Reference Antibody (erenumab) APR10013
    Immobilized human CGRPR VLP Protein at 16 µg/mL can bind Anti-CALCRL / CGRPR Reference Antibody (erenumab),EC50=0.0206 µg/mL.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC, E, FTA
Primary Accession Q16602
Reactivity Cynomolgus, Human
Clonality Monoclonal
Isotype IgG2SA
Calculated MW 146.2 KDa
Additional Information
Target/Specificity CALCRL / CGRPR
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name CALCRL (HGNC:16709)
Synonyms CGRPR
Function G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2 (PubMed:33602864). Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2) (PubMed:32296767, PubMed:9620797). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32296767, PubMed:8626685).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Predominantly expressed in the lung and heart.
Research Areas
Citations (0)
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$ 385.00
Cat# APR10013
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Availability: 4 weeks
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