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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-CALCRL / CGRPR Reference Antibody (erenumab)
Anti-CALCRL / CGRPR Reference Antibody (erenumab)
Recombinant Antibody
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- BACKGROUND
Application 
| FC, E, FTA |
|---|---|
| Primary Accession | Q16602 |
| Reactivity | Cynomolgus, Human |
| Clonality | Monoclonal |
| Isotype | IgG2SA |
| Calculated MW | 146.2 KDa |
| Target/Specificity | CALCRL / CGRPR |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Name | CALCRL (HGNC:16709) |
|---|---|
| Synonyms | CGRPR |
| Function | G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2 (PubMed:33602864). Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2) (PubMed:32296767, PubMed:9620797). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32296767, PubMed:8626685). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Predominantly expressed in the lung and heart. |
Research Areas
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$ 385.00
Cat# APR10013
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