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TTF-1
Rabbit Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC |
|---|---|
| Primary Accession | P43699 |
| Host | Rabbit |
| Clonality | Monoclonal |
| Calculated MW | 38596 Da |
| Gene ID | 7080 |
|---|---|
| Gene Name | NKX2-1 (HGNC:11825) |
| Other Names | Homeobox protein Nkx-2.1, Homeobox protein NK-2 homolog A, Thyroid nuclear factor 1, Thyroid transcription factor 1, TTF-1, Thyroid-specific enhancer-binding protein, T/EBP, NKX2-1 (HGNC:11825), NKX2A, TITF1, TTF1 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TTF-1 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NKX2-1 (HGNC:11825) |
|---|---|
| Synonyms | NKX2A, TITF1, TTF1 |
| Function | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P50220}. |
| Tissue Location | Thyroid and lung. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 1,000.00
Cat# APA352
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