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CIRH1A Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q969X6 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 76890 Da |
| Antigen Region | 116-143 aa |
| Gene ID | 84916 |
|---|---|
| Other Names | Cirhin, CIRH1A, KIAA1988, UTP4 |
| Target/Specificity | This CIRH1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-143 amino acids from the N-terminal region of human CIRH1A. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CIRH1A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UTP4 (HGNC:1983) |
|---|---|
| Function | Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted d Involved in SSU pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766, PubMed:34516797). May be a transcriptional regulator (PubMed:22916032). |
| Cellular Location | Nucleus, nucleolus. Chromosome Note=Found predominantly at the fibrillar center |
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Provided below are standard protocols that you may find useful for product applications.
Background
CIRH1A encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence.
References
Yu, B., et al. Exp. Cell Res. 315(18):3086-3098(2009) Carlton, V.E., et al. Ann. Med. 36(8):606-617(2004)
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