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ICB1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q5TEJ8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 72049 Da |
| Antigen Region | 613-641 aa |
| Gene ID | 9473 |
|---|---|
| Other Names | Protein THEMIS2, Induced by contact to basement membrane 1 protein, Protein ICB-1, Thymocyte-expressed molecule involved in selection protein 2, THEMIS2, C1orf38, ICB1 |
| Target/Specificity | This ICB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-641 amino acids from the C-terminal region of human ICB1. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ICB1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | THEMIS2 (HGNC:16839) |
|---|---|
| Function | May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q91YX0}. Cytoplasm {ECO:0000250|UniProtKB:Q91YX0} |
| Tissue Location | Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1 |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Involved in cell adhesion. There are 4 isoforms produced by alternative splicing.
References
Springwald, A., et al. Cancer Invest. 27(6):669-672(2009)
Treeck, O., et al. Cytokine 32 (3-4), 137-142 (2005)
Treeck, O., et al. Leuk. Res. 26(8):765-769(2002)
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$ 182.50
$ 70.00
Cat# AP9910b
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