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ST8SIA4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q92187 |
| Other Accession | Q64692, Q6ZXC9 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41295 Da |
| Antigen Region | 186-214 aa |
| Gene ID | 7903 |
|---|---|
| Other Names | CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase, 2499-, Alpha-2, 8-sialyltransferase 8D, Polysialyltransferase-1, Sialyltransferase 8D, SIAT8-D, Sialyltransferase St8Sia IV, ST8SiaIV, ST8SIA4, PST, PST1, SIAT8D |
| Target/Specificity | This ST8SIA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-214 amino acids from the Central region of human ST8SIA4. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ST8SIA4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ST8SIA4 (HGNC:10871) |
|---|---|
| Function | Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8- linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages (PubMed:10766765, PubMed:11279095, PubMed:28810663, PubMed:9774483). Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG (PubMed:10766765, PubMed:11279095, PubMed:28810663, PubMed:9774483). It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid (PubMed:9774483). |
| Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. Secreted |
| Tissue Location | Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus (PubMed:7624364). Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes (PubMed:7624364) |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus.
References
Johnson, M.P., et al. Hum. Genet. 126(5):655-666(2009)
Foley, D.A., et al. J. Biol. Chem. 284(23):15505-15516(2009)
Otowa, T., et al. J. Hum. Genet. 54(2):122-126(2009)
Sonuga-Barke, E.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1359-1368 (2008) :
Schreiber, S.C., et al. Gastroenterology 134(5):1555-1566(2008)
Close, B.E., et al. Glycobiology 11(11):997-1008(2001)
Angata, K., et al. J. Biol. Chem. 276(18):15369-15377(2001)
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