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T4S4 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P48230 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21396 Da |
| Antigen Region | 16-45 aa |
| Gene ID | 7104 |
|---|---|
| Other Names | Transmembrane 4 L6 family member 4, Intestine and liver tetraspan membrane protein, IL-TMP, TM4SF4, ILTMP |
| Target/Specificity | This T4S4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human T4S4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | T4S4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TM4SF4 |
|---|---|
| Synonyms | ILTMP |
| Function | Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Jejunum and liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
T4S4 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation. The use of alternate polyadenylation sites has been found for this gene.
References
Qiao, J., et al. Reprod. Biomed. Online 17(3):425-435(2008)
Berditchevski, F. J. Cell. Sci. 114 (PT 23), 4143-4151 (2001)
Wright, M.D., et al. Protein Sci. 9(8):1594-1600(2000)
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