CTSD Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P07339 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 44552 Da |
Antigen Region | 377-408 aa |
Gene ID | 1509 |
---|---|
Other Names | Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD |
Target/Specificity | This CTSD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-408 amino acids from the C-terminal region of human CTSD. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CTSD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CTSD |
---|---|
Synonyms | CPSD |
Function | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. |
Cellular Location | Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380) |
Tissue Location | Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530). |
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Provided below are standard protocols that you may find useful for product applications.
Background
CTSD encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript.
References
Christensen, B., et al. J. Biol. Chem. 285(11):7929-7937(2010)
Albayrak, O., et al. J. Gerontol. A Biol. Sci. Med. Sci. 65(3):219-224(2010)
Heinrich, M., et al. EMBO J. 18(19):5252-5263(1999)
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