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HNF4A Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • IF - HNF4A Antibody (N-term) AP9435a
    Confocal immunofluorescent analysis of HNF4A Antibody (N-term)(Cat#AP9435a) with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
    detail
  • WB - HNF4A Antibody (N-term) AP9435a
    Anti-HNF4A Antibody (N-term) at 1:1000 dilution + human liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 53 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IF, WB, E
Primary Accession P41235
Other Accession Q9WUU6, Q14541, Q91766, P22449, P49698
Reactivity Human
Predicted Mouse, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 52785 Da
Antigen Region 107-139 aa
Additional Information
Gene ID 3172
Other Names Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14
Target/Specificity This HNF4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-139 amino acids from the N-terminal region of human HNF4A.
Dilution IF~~1:10~50
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHNF4A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNF4A
Synonyms HNF4, NR2A1, TCF14
Function Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698).
Cellular Location Nucleus.
Research Areas
Citations (0)
citation

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Background

HNF4A is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines.

References

Koh, W., et al. BMC Genomics 11 SUPPL 1, S6 (2010)
Wang, F., et al. Chin. Med. J. 122(20):2477-2482(2009)
Taghavi, S.M., et al. Cardiovasc Diabetol 8, 63 (2009)
Guo, H., et al. Biochem. J. 394 (PT 2), 379-387 (2006)
Hong, Y.H., et al. J. Biol. Chem. 278(30):27495-27501(2003)

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$ 365.00
$ 140.00
Cat# AP9435a
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