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IFNGR1 Rabbit pAb
IFNGR1 Rabbit pAb
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P15261 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52343 Da |
| Gene ID | 15979 |
|---|---|
| Other Names | Interferon gamma receptor 1 {ECO:0000312|MGI:MGI:107655}, IFN-gamma receptor 1, IFN-gamma-R1, Interferon gamma receptor alpha-chain, CD119, Ifngr1 {ECO:0000312|MGI:MGI:107655}, Ifngr |
| Dilution | WB=1:500-2000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | Ifngr1 {ECO:0000312|MGI:MGI:107655} |
|---|---|
| Synonyms | Ifngr |
| Function | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:2137461, PubMed:2530216, PubMed:2530582, PubMed:2531896, PubMed:2532365). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:19889125). STAT3 can also be activated in a similar manner although activation seems weaker (PubMed:15284232). IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (PubMed:15522878). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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$ 385.00
Cat# AP94130
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