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SLC1A5 Rabbit pAb
SLC1A5 Rabbit pAb
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Application 
| WB |
|---|---|
| Primary Accession | P51912 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58483 Da |
| Other Names | Neutral amino acid transporter B(0), ATB(0), ASC-like Na(+)-dependent neutral amino acid transporter ASCT2, Insulin-activated amino acid transporter, Sodium-dependent neutral amino acid transporter type 2, Solute carrier family 1 member 5, Slc1a5, Aaat, Asct2, Slc1a7 |
|---|---|
| Dilution | WB=1:500-2000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | Slc1a5 |
|---|---|
| Synonyms | Aaat, Asct2, Slc1a7 |
| Function | Sodium-coupled antiporter of neutral amino acids. In a tri- substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (By similarity) (PubMed:7702599, PubMed:8662767). The preferred substrate is the essential amino acid L- glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (By similarity). The transport cycle is usually pH-independent, with the exception of L- glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (By similarity). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (By similarity). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q15758}. Melanosome {ECO:0000250|UniProtKB:Q15758} |
| Tissue Location | Highly expressed in adipose tissue. Detected in lung, skeletal muscle, large intestine, kidney and testis (PubMed:7702599, PubMed:8662767). Expressed in lung, brain, kidney and neural retina (at protein level). Expressed in Mueller cells (at protein level) (PubMed:17094966). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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$ 385.00
Cat# AP94125
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