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LRRC50 (11E13) Mouse Monoclonal antibody
LRRC50 (11E13) Mouse Monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8NEP3 |
| Reactivity | Rat, Human, Mouse, Monkey, Dog |
| Clonality | Monoclonal |
| Calculated MW | 80026 Da |
| Gene ID | 123872 |
|---|---|
| Other Names | Dynein axonemal assembly factor 1, Leucine-rich repeat-containing protein 50, DNAAF1, LRRC50 |
| Storage Conditions | -20℃ |
| Name | DNAAF1 |
|---|---|
| Synonyms | LRRC50 |
| Function | Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli. |
| Cellular Location | Cell projection, cilium. Cytoplasm Cytoplasm, cytoskeleton, spindle pole Note=In HEK293T cells, it is diffusely cytoplasmic and concentrates at the mitotic spindle poles, while in MDCK cells, it localizes in the cilium. In vivo, this protein is probably restricted to the cilium |
| Tissue Location | Mainly expressed in trachea and testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is cilium-specific and is required for the stability of the ciliary architecture. It is involved in the regulation of microtubule-based cilia and actin-based brush border microvilli. Mutations in this gene are associated with primary ciliary dyskinesia-13. COMPLETENESS: complete on the 3' end.
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