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HSCB (11S6) Mouse Monoclonal antibody

HSCB (11S6) Mouse Monoclonal antibody

     
  •  - HSCB (11S6) Mouse Monoclonal antibody AP93906
    Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-HSCB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min, AP93906)
    detail
  •  - HSCB (11S6) Mouse Monoclonal antibody AP93906
    Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-HSCB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min, AP93906)
    detail
  •  - HSCB (11S6) Mouse Monoclonal antibody AP93906
    Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-HSCB monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
    detail
  •  - HSCB (11S6) Mouse Monoclonal antibody AP93906
    Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-HSCB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min, AP93906)
    detail
  •  - HSCB (11S6) Mouse Monoclonal antibody AP93906
    Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-HSCB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min, AP93906)
    detail
  •  - HSCB (11S6) Mouse Monoclonal antibody AP93906
    Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-HSCB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min, AP93906)
    detail
  •  - HSCB (11S6) Mouse Monoclonal antibody AP93906
    Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-HSCB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min, AP93906)
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q8IWL3
Reactivity Rat, Human, Mouse, Monkey, Dog
Clonality Monoclonal
Calculated MW 27422 Da
Additional Information
Gene ID 150274
Other Names Iron-sulfur cluster co-chaperone protein HscB, DnaJ homolog subfamily C member 20, Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic, C-HSC20, Iron-sulfur cluster co-chaperone protein HscB, mitochondrial, HSCB (HGNC:28913), DNAJC20, HSC20
Storage Conditions-20℃
Protein Information
Name HSCB (HGNC:28913)
Synonyms DNAJC20, HSC20
Function [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria (PubMed:20668094). Required for incorporation of iron- sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain (PubMed:26749241). Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (PubMed:26749241). Plays an essential role in hematopoiesis (By similarity).
Cellular Location [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Cytoplasm
Tissue Location Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart.
Research Areas
Citations (0)
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Cat# AP93906
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