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POLR2J2 (3R19) Mouse Monoclonal antibody
POLR2J2 (3R19) Mouse Monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9GZM3 |
| Reactivity | Rat, Human, Monkey, Dog |
| Clonality | Monoclonal |
| Calculated MW | 13088 Da |
| Gene ID | 246721;548644 |
|---|---|
| Other Names | DNA-directed RNA polymerase II subunit RPB11-b1, RNA polymerase II subunit B11-b1, RPB11b1, DNA-directed RNA polymerase II subunit J2, POLR2J2 |
| Storage Conditions | -20℃ |
| Name | POLR2J2 |
|---|---|
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq]
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