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ASCC2 (13J8) Mouse Monoclonal antibody

ASCC2 (13J8) Mouse Monoclonal antibody

     
  •  - ASCC2 (13J8) Mouse Monoclonal antibody AP93894
    Flow cytometric Analysis of Hela cells, using anti-ASCC2 antibody (AP93894), (Red), compared to a nonspecific negative control antibody , (Blue).
    detail
  •  - ASCC2 (13J8) Mouse Monoclonal antibody AP93894
    Anti-ASCC2 mouse monoclonal antibody (AP93894) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ASCC2.
    detail
  •  - ASCC2 (13J8) Mouse Monoclonal antibody AP93894
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ASCC2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ASCC2(Cat# AP93894). Positive lysates (100ug) and (20ug) can be purchased separately from biodragon.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IF
Primary Accession Q9H1I8
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Calculated MW 86360 Da
Additional Information
Gene ID 84164
Other Names Activating signal cointegrator 1 complex subunit 2, ASC-1 complex subunit p100, Trip4 complex subunit p100, ASCC2, ASC1P100, RQT3 {ECO:0000303|PubMed:32099016}
Storage Conditions-20℃
Protein Information
Name ASCC2
Synonyms ASC1P100, RQT3 {ECO:0000303|PubMed:32099
Function Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773).
Cellular Location Nucleus. Nucleus speckle Note=Colocalizes with the spliceosomal components PRPF8 and SNRNP200/BRR2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Colocalizes with RNF113A and 'Lys-63'-linked polyubiquitinated proteins, ALKBH3 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage.
Tissue Location Ubiquitous..
Research Areas
Citations (0)
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Cat# AP93894
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