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> home > Products > Primary Antibodies > Signal Transduction > ASCC2 (13J8) Mouse Monoclonal antibody
ASCC2 (13J8) Mouse Monoclonal antibody
ASCC2 (13J8) Mouse Monoclonal antibody
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- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | Q9H1I8 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Calculated MW | 86360 Da |
| Gene ID | 84164 |
|---|---|
| Other Names | Activating signal cointegrator 1 complex subunit 2, ASC-1 complex subunit p100, Trip4 complex subunit p100, ASCC2, ASC1P100, RQT3 {ECO:0000303|PubMed:32099016} |
| Storage Conditions | -20℃ |
| Name | ASCC2 |
|---|---|
| Synonyms | ASC1P100, RQT3 {ECO:0000303|PubMed:32099 |
| Function | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). |
| Cellular Location | Nucleus. Nucleus speckle Note=Colocalizes with the spliceosomal components PRPF8 and SNRNP200/BRR2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Colocalizes with RNF113A and 'Lys-63'-linked polyubiquitinated proteins, ALKBH3 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. |
| Tissue Location | Ubiquitous.. |
Research Areas
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Application Protocols
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Cat# AP93894
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