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MICAL1 (18N18) Mouse Monoclonal antibody
MICAL1 (18N18) Mouse Monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF |
|---|---|
| Primary Accession | Q8TDZ2 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Calculated MW | 117875 Da |
| Gene ID | 64780 |
|---|---|
| Other Names | [F-actin]-monooxygenase MICAL1, 1.14.13.225, 1.6.3.1, Molecule interacting with CasL protein 1, MICAL-1, NEDD9-interacting protein with calponin homology and LIM domains, MICAL1, MICAL, NICAL |
| Storage Conditions | -20℃ |
| Name | MICAL1 |
|---|---|
| Synonyms | MICAL, NICAL |
| Function | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (PubMed:32344433). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Endosome membrane. Midbody Note=Accumulates transiently at the abscission site before abscission occurs. Colocalized with GRAF1/ARHGAP26 and GRAF2/ARHGAP10, RAB8A, RAB8B and RAB10 on endosomal tubules (PubMed:32344433) |
| Tissue Location | Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells. |
Research Areas
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Cat# AP93887
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