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TTLL12 (11R19) Mouse Monoclonal antibody

TTLL12 (11R19) Mouse Monoclonal antibody

     
  •  - TTLL12 (11R19) Mouse Monoclonal antibody AP93878
    HEK293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-TTLL12 antibody (AP93878), and then analyzed by flow cytometry.
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  •  - TTLL12 (11R19) Mouse Monoclonal antibody AP93878
    Flow cytometric Analysis of Jurkat cells, using anti-TTLL12 antibody (AP93878), (Red), compared to a nonspecific negative control antibody, (Blue).
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  •  - TTLL12 (11R19) Mouse Monoclonal antibody AP93878
    Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-TTLL12 monoclonal antibody.
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  •  - TTLL12 (11R19) Mouse Monoclonal antibody AP93878
    Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TTLL12 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, AP93878)
    detail
  •  - TTLL12 (11R19) Mouse Monoclonal antibody AP93878
    Anti-TTLL12 mouse monoclonal antibody (AP93878) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TTLL12 .
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  •  - TTLL12 (11R19) Mouse Monoclonal antibody AP93878
    Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-TTLL12 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, AP93878)
    detail
  •  - TTLL12 (11R19) Mouse Monoclonal antibody AP93878
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TTLL12 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TTLL12. Positive lysates (100ug) and (20ug) can be purchased separately from biodragon.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF
Primary Accession Q14166
Reactivity Rat, Human, Mouse, Monkey, Dog
Clonality Monoclonal
Calculated MW 74404 Da
Additional Information
Gene ID 23170
Other Names Tubulin--tyrosine ligase-like protein 12, Inactive tubulin--tyrosine ligase-like protein 12, TTLL12, KIAA0153
Storage Conditions-20℃
Protein Information
Name TTLL12
Synonyms KIAA0153
Function Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).
Cellular Location Cytoplasm. Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus Note=Predominantly localizes in the cytoplasm (PubMed:28011935) Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578).
Tissue Location Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions.
Research Areas
Citations (0)
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Cat# AP93878
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