TTLL12 (11R19) Mouse Monoclonal antibody
TTLL12 (11R19) Mouse Monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC, IF |
---|---|
Primary Accession | Q14166 |
Reactivity | Rat, Human, Mouse, Monkey, Dog |
Clonality | Monoclonal |
Calculated MW | 74404 Da |
Gene ID | 23170 |
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Other Names | Tubulin--tyrosine ligase-like protein 12, Inactive tubulin--tyrosine ligase-like protein 12, TTLL12, KIAA0153 |
Storage Conditions | -20℃ |
Name | TTLL12 |
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Synonyms | KIAA0153 |
Function | Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935). |
Cellular Location | Cytoplasm. Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus Note=Predominantly localizes in the cytoplasm (PubMed:28011935) Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578). |
Tissue Location | Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions. |

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