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FXYD3 (15L6) Mouse Monoclonal antibody

FXYD3 (15L6) Mouse Monoclonal antibody

     
  •  - FXYD3 (15L6) Mouse Monoclonal antibody AP93862
    Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-FXYD3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, AP93862)
    detail
  •  - FXYD3 (15L6) Mouse Monoclonal antibody AP93862
    Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-FXYD3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, AP93862)
    detail
  •  - FXYD3 (15L6) Mouse Monoclonal antibody AP93862
    Western blot analysis of extracts (35ug) from 9 different cell lines by usin g anti-FXYD3 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
    detail
  •  - FXYD3 (15L6) Mouse Monoclonal antibody AP93862
    Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-FXYD3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, AP93862)
    detail
  •  - FXYD3 (15L6) Mouse Monoclonal antibody AP93862
    Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-FXYD3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, AP93862)
    detail
  •  - FXYD3 (15L6) Mouse Monoclonal antibody AP93862
    Anti-FXYD3 mouse monoclonal antibody (AP93862) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FXYD3 .
    detail
  •  - FXYD3 (15L6) Mouse Monoclonal antibody AP93862
    Immunohistochemical staining of paraffin-embedded Human bladder tissue within the normal limits using anti-FXYD3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, AP93862)
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF
Primary Accession Q14802
Reactivity Human
Clonality Monoclonal
Calculated MW 9263 Da
Additional Information
Gene ID 5349
Other Names FXYD domain-containing ion transport regulator 3, Chloride conductance inducer protein Mat-8, Mammary tumor 8 kDa protein, Phospholemman-like, Sodium/potassium-transporting ATPase subunit FXYD3, FXYD3, MAT8, PLML
Storage Conditions-20℃
Protein Information
Name FXYD3
Synonyms MAT8, PLML
Function Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Isoform 1: Expressed mainly in differentiated cells (at protein level). Isoform 2: Expressed mainly in undifferentiated cells (at protein level).
Research Areas
Citations (0)
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Background

This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Cat# AP93862
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