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CALCOCO2 (14R16) Mouse Monoclonal antibody

CALCOCO2 (14R16) Mouse Monoclonal antibody

     
  •  - CALCOCO2 (14R16) Mouse Monoclonal antibody AP93859
    HEK293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-CALCOCO2 antibody (AP93859), and then analyzed by flow cytometry.
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  •  - CALCOCO2 (14R16) Mouse Monoclonal antibody AP93859
    Flow cytometric Analysis of Jurkat cells, using anti-CALCOCO2 antibody (AP93859), (Red), compared to a nonspecific negative control antibody, (Blue).
    detail
  •  - CALCOCO2 (14R16) Mouse Monoclonal antibody AP93859
    Figure from citation: Western Blot of CALCOCO2 (NDP52) protein level by using anti-CALCOCO2 antibody in human HEp-2 cell lysates.
    detail
  •  - CALCOCO2 (14R16) Mouse Monoclonal antibody AP93859
    Flow cytometric Analysis of Hela cells, using anti-CALCOCO2 antibody (AP93859), (Red), compared to a nonspecific negative control antibody, (Blue).
    detail
  •  - CALCOCO2 (14R16) Mouse Monoclonal antibody AP93859
    Western blot analysis of extracts (10ug) from 9 Human tissue by using anti-CALCOCO2 monoclonal antibody at 1:200 (1: Testis; 2: Omentum; 3: Uterus; 4: Breast; 5: Brain; 6: Liver; 7: Ovary; 8: Thyroid gland; 9: colon).
    detail
  •  - CALCOCO2 (14R16) Mouse Monoclonal antibody AP93859
    Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-CALCOCO2 monoclonal antibody.
    detail
  •  - CALCOCO2 (14R16) Mouse Monoclonal antibody AP93859
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CALCOCO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CALCOCO2(Cat# AP93859). Positive lysates (100ug) and (20ug) can be purchased separately from biodragon.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IF
Primary Accession Q13137
Reactivity Human, Monkey
Clonality Monoclonal
Calculated MW 52254 Da
Additional Information
Gene ID 10241
Other Names Calcium-binding and coiled-coil domain-containing protein 2, Antigen nuclear dot 52 kDa protein, Nuclear domain 10 protein NDP52, Nuclear domain 10 protein 52, Nuclear dot protein 52, CALCOCO2, NDP52 {ECO:0000303|PubMed:7540613}
Storage Conditions-20℃
Protein Information
Name CALCOCO2
Synonyms NDP52 {ECO:0000303|PubMed:7540613}
Function Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).
Cellular Location Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus.
Tissue Location Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a subunit of nuclear domain 10 (ND10) bodies. ND10 bodies are nuclear domains appearing immunohistochemically as ten dots per nucleus. They are believed to be associated with the nuclear matrix on the basis of their resistance to nuclease digestion and salt extraction. ND10 proteins are removed from the nucleus by herpes simplex virus-1 infection and may have a role in viral life cycles. [provided by RefSeq]. COMPLETENESS: complete on the 3' end.

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Cat# AP93859
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